The elemental iron product used is Iron sucrose 20 mg/mL. Reference www.medicines.org.uk Background Applies only to oral form of both agents. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Formula for calculating the required dose of iron sucrose 1. I. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Pain, swelling, or redness at the injection site may occur. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] This drug is available at a middle level co-pay. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Use Caution/Monitor. Use Caution/Monitor. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. 1. To view formulary information first create a list of plans. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. This site contains information for licensed healthcare professionals in the United States. Information last revised December 2022. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. This drug is available at the lowest co-pay. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. The recipient will receive more details and instructions to access this offer. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Adding plans allows you to compare formulary status to other drugs in the same class. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Administer Venofer early during the dialysis session (generally within the first hour). Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Learn how to store and discard medical supplies safely. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Generic name: IRON SUCROSE 20mg in 1mL Ferritin and transferrin are also recommended monitoring . Calculates iron deficit for dosing iron. Applies only to oral form of both agents. Applies only to oral form of both agents. 2000 Jan;22(1):39-43. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. The dosage of Venofer is expressed in mg of elemental iron. Oral and parenteral products - see background option for oral products. . Applies only to oral form of both agents. Avoid or Use Alternate Drug. commonly, these are generic drugs. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Minor/Significance Unknown. 4. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Oral and parenteral products - see background option for oral products. Observed Hb = the patients current hemoglobin in g/dl. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Intravenous iron-dextran: therapeutic and experimental possibilities. Creating an account is free and takes less than 1 minute. Share cases and questions with Physicians on Medscape consult. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. 3. Before using, check this product visually for particles or discoloration. Interaction only with oral iron administration. US residents can call their local poison control center at 1-800-222-1222. Controlled studies in pregnant women show no evidence of fetal risk. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Anemia caused by the depletion of iron is called iron deficiency anemia. Shirley, NY: American Regent, Inc.; 9/2020. The dosage of iron sucrose is expressed in mg of elemental iron. Applies only to oral form of both agents. Patients measured hemoglobin can be input in g/dL or mmol/L. Minor/Significance Unknown. You may report side effects to Health Canada at 1-866-234-2345. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. May increase risk of hypotension. Where: Medicine concentration Amount of active substance per a given volume of your drug. Either increases effects of the other by pharmacodynamic synergism. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Use Caution/Monitor. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Applies only to oral form of both agents. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Methods. The primary endpoint was the proportion of patients with . Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Compare formulary status to other drugs in the same class. Modify Therapy/Monitor Closely. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Applies only to oral form of both agents. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. J Lab Clin Med. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor (1)iron sucrose, captopril. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. 1000 mg. 20 MINUTES. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Applies only to oral form of both agents. Administer on 5 different occasions over a 14 day period. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Applies only to oral form of both agents. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. This calculator will help pinpoint potential causes of anemia based on Kumpf VJ. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Minor/Significance Unknown. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Minor/Significance Unknown. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Use Caution/Monitor. Most Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). commonly, these are "non-preferred" brand drugs or specialty Hollands J, Foote E, Rodriguez A. This website also contains material copyrighted by 3rd parties. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia.