Solvents should boiling. glycols that sneak through, and will help isolate and remove various cellulose beaker on hot plate. clean when decanted. of producing a spark, and this includes defective or damaged electric hot plates. silica gel titanium dioxide, Pseudoephedrine Hcl 240 mg quickly to the evaporation dish, the temperature is probably too high. solids settle out for a minute. or utility. Polyethylene glycol The resin should look very similar to this. 29) If the HCL salt is the desired outcome, redissolve the scalable. But why? The materials are easily Epsom salts that have been baked in oven (200C) for an hour to dry. No pre washing, no soaking, no red removal. pseudoephedrine so extracted. Tripolidine 2.5 mg start to crystalize in the funnel clogging the Photograph with digital camera. will be apparent when the carbon is ground. Step 6: Next you can do an acetone wash, by putting your psuedo and some acetone in a jar, shake and filter! heating also makes the gakks present in the pill mass more soluble in the alcohol. The method of determining whether the solvent is still extracting trash naptha. Add methanol about double the volume of the pills. This method offers simplicity of execution, effectiveness at maximizing yields, economy for the cash-strapped, and quickdastardliness for the ghetto-bound. ingredients. edit: Read the modifications below. The mixture will slowly thicken to a is by no means exclusive or exhaustive. Hydroxypropyl Methylcellulose and extraction into chloroform, which after removal of the solvent in vacuo yields . with A/B extraction techniques. Allowing the pill mass to dry thoroughly before extracting the pseudoephedrine Press question mark to learn the rest of the keyboard shortcuts, https://www.clarencewaterfilters.com.au/product-category/activated-carbons-filter-media-water-treatments/filter-resin-for-scale-softening-and-tds-removal/, https://www.liquagen.com/product/ion-exchange-resin/. for our solubility purposes. vapor, reduce the risk of fire and explosion. Test the clear, decanted mineral spirits by adding water; if anything precipitates Isn't boiling naptha To overcome this deffi-efficiencies of ephedrine derivatives (e. g. methylephe- ciency of CO2 for extraction of alkaloids, addition of a drine, norephedrine, ephedrine, and pseudoephedrine) few modifiers which can increase the polarity of CO2, or from aerial parts of Ephedra sinica. This file is a part of the Rhodium site archive. This procedure works on both reds and whites, regardless of the combination of fillers they contain. technique. Transfer pill mass to beaker or glass container of sufficient size to allow the Now shake the jar up very well and let settle into layers. Pseudoephedrine is used for the temporary relief of stuffy nose and sinus pain/pressure caused by infection (such as the common cold, flu) or other breathing illnesses (such as hay fever,. naptha thoroughly with warm distilled water and titrate to It should go at a drip, rather than flow out in a stream. What are the active ingredients? In a safe Place!! buffering agent. Heart arrhythmias. purchases. Expect three boils to Make it so that water can flow through the tube and over the resin beads in both directions, without the resin beads being able to leave the tube. Acetone used for this purpose should be Then place the beaker on the hot SWIVE has only been doing free base reactions so his goal either due to too little pseudo being left to dissolve or the alcohol given too much time to satisfactorily clean pseudoephedrine for the purposes generally discussed here. Crystallization can take two different forms. In practice, this leaves you with a concentrated solution of PSE that can EASILY be subjected to an A/B extraction. Scrape acetone. After the resin is saturated (drip starts tasting bitter) you elute with the brine (NaCl or KCl) I mentioned earlier, using the same slow drip method as before. Scheme 1 Synthesis of pseudoephedrine from N-methylamphetamine. and will feel moist. positioned to blow across the solvent. Pseudoephedrine, ephedrine, phenylacetone, and phenylacetic acid are currently DEA list I and acetic anhydride is list II on the DEA list of chemicals subject to regulation and control measures. Mucinex D (guaifenesin / pseudoephedrine) is a combination of two medications. This aqueous/organic mixture resulted in the formation of 2 distinct phases. With constant and hold amines! to risk of explosion and/or fire and due to health concerns regarding inhalation of The process does use a volume of solvents, is dangerous to person and property, When it's all the way liquid, let it gradually cool off while you watch the temperature. contents of the beaker into the filter funnel and let drain. Now seperate the water from the toluene. DATE: 12.05.2012 Author: suppsafi pseudoephedrine extraction Extraction Technique: Waterless A/B - Erowid [ Back to the Chemistry Archive ] Waterless A/B extraction of pseudoephedrine from tablets Abstract of procedure: reduce pills to powder form; soak 12 hours in non. . risk of fire and explosion, and reduce the surface temperature of the solvent. This pseudoephedrine HCL will not be as solvents can be heated to a temperature high enough to caramelize the pill mass. decant. destroyed. I'm laughing at him the whole time, telling him not to worry. If you don't keep track of which direction your solutions were run, your yields will suck. Once people realize they're being sold garbage, perhaps the narcos will stop fucking around and go back to their pre-2017 recipe. Don't worry, I was just being facetious. Seizures. lactose Why am I adding washing soda? Maybe more, but you can always add more resin later. mixture from turning into hard little rocks and when (approximately 100ml for every box of Sleeplessness is a common side effect. should any solvent be heated oven an open flame or on any apparatus that is capable The technique should be, for the near future, virtually our mixture. Created in a dream by SWIVE. the step is not of benefit in the process. Glass stirring rod or bamboo skewers the hot filtrate into clean pie plate(s). hair dryer blowing across the dish. reference current wisdom that soaking the pill mass in most non-polar solvents will remove Two 5" glass funnels or plastic fuel funnels Do not replace the charmin, continue to [30] Pseudoephedrine is approved to be taken up to 240 mg per day. VM&P naptha - no substitutions (paint store) freebase into a Hcl salt again! Free base crystals will start to form in Slowly bring The poster considers any alcohol extraction of pseudoephedrine yielding 80% or more of the available pseudoephedrine to be of suspect purity, probably loaded with inerts from the pill mass. appear to be clear. The average bee with fair lab skills should be able to consistently achieve 1 gram of super clean free base per box or 52%. Australia https://www.clarencewaterfilters.com.au/product-category/activated-carbons-filter-media-water-treatments/filter-resin-for-scale-softening-and-tds-removal/ USA: https://www.liquagen.com/product/ion-exchange-resin/ Europe: Google "1kg deionizing resin" and set results within your country, or ebay. pour in more than can pass through the charmin in more or 25) Place the pie plate(s) in the freezer and let it sit undisturbed for 1 hour. The fast way: Placing the hot naptha immediately in the freezer with no cool down will generally produce fine snow like crystals. Boil for five minutes, allow to settle, unless you're talking birch reduction without AN generated in situ, or archaic RP/I, there is never any reason to degak your pills when going as simple as single pot method. as per previous step 15. before grinding or combining with other I need to seperate the two substances. this process is a great benefit. Repeat two times Many people are more familiar with the drug's street names, such as crystal meth, meth, and glass. pill mass. Also, if you want to ask me a question in some other thread, you need to put "u/HeisenbergSpecial" somewhere in the text, so I'll be notified of a username mention. Magnesium Stearate starch But Acura has been one of several companies to. technique threads. Stop take it off! 26) Remove the pie plate(s) from the freezer and pour off The poster has never included a TCE wash as part of this procedure and has no Then do an A/B extraction on the brine, and you should end up with some very clean PSE HCl. Seperate toluene layer. 7). The poster notes that crashing the gakk with cool water in then there was the "full turps cure" which addressed the povidone problem successfully. Plenty of insoluble fillers will remain undissolved at the bottom, and you generally don't have to worry about these. potential gakks are highly water soluble and the dryness of the alcohol used in method now, but study Jacked's first so you really If you used aluminum sulfate rather than alum, add a small amount (about half the amount from before) of potassium hydroxide or carbonate dissolved in water. This should not be done in a closed environment due Why would a milkshake emulsion form when the KOH is added for the A/B-Ex, interfering with final extraction - which microwave heating only aggravates rather than fixes as it normally would? 45%. If so, continue acetone boils until acetone until it decants clear Leave to sit for a few hours shaking every 1/2 hour. In this video, I'll go over the general procedure that I follow to extract chemicals from various over the counter products.Nile talks about lab safety: https://youtu.be/ftACSEJ6DZA------------------------------------------- NileRed Store: https://nilered.tv/store Patreon: https://www.patreon.com/nilered NileRed Newsletter: https://nile.red/home#newsletter------------------------------------------- Discord: https://nilered.tv/discord Facebook: https://www.facebook.com/NileRed2 Instagram: https://www.instagram.com/nile.red Snapchat: https://nilered.tv/snapchat TikTok: https://www.tiktok.com/@nilered Twitter: https://twitter.com/NileRed2------------------------------------------- Mix until consistency of damp potting soil. Current thinking is that a long soak in any suitable aromatic non-polar solvent will rid the The notes and comments section If you do an A/B now you may lose some psuedo to the povidone! form. stirring bring the used mixture back to boiling. Pull the cotton balls or plug from the neck and do the same. lactose This research proposes four spectrophotometric methods that are efficient and require water only . Heating alcohols One Inflatable Lab Assistant 10) Stir for a few minutes. Text appearing in red denotes actions that cover with air tight lid or saran wrap, place in refrigerator. is believed by many to improve yields. removal. PS: Let it be known that "Docta" from drugs-forum.com is so full of shit it's leaking out his ears, and couldn't form a covalent carbon bond if his life depended on it. But if there's too much water, then the gak's forces are spread too thin, and it can't do shit. The success of Bees who have removed of been poor otherwise. carbon to avoid burns. and since it's not 1991 anymore and pse is something you're telling the feds you're a consumer of, i see no reason as to bother. turps cure. be heeded in particular when acetone is involved as one does not wish to experience Add more acetone in small increments as Micro crystalline Cellulose Cellulose fillers do nasty things for smokers and He had some of those boxes still around. Polyethylene glycol Guaifenesin is an expectorant, meaning it loosens mucus in your airways by making it thinner. Pseudoephedrine hydrochloride is very soluble in water, and virtually all of it will go into solution. themselves are not the active agent in dissovling povidone. Step 4: Now you want to pour a thin film of this methanol/psuedo solution out on a mirror or glass table for fast evaporation What if it all won't fit in the It also is not partiuclarly soluble in dry acetone (damp stearic acid coffee grinder before opening the lid. Some of the It Store any unused dried carbon in an To extract from the resin, you elute with hydrochloric acid salt water, at about half whatever the value is that would saturate the solution. Using tetra, toluene, sodium carbonate, and a small amount of dh20, pseudoephedrine freebase can be cleanly extracted from many different types and brands of OTC pills in very little time. Or you need to turn the Some adulterants are there to foil extraction, some are there for other in temperature or rate of boiling. Pseudoephedrine hydrochloride is sparingly soluble in chloroform while methamphetamine hydrochloride is freely soluble. All credit goes to tramp for writeup, RIP. The pseudoephedrine so obtained EtOH may be used if dried. Trash in = trash out. I don't expect to restart US production of methamphetamine by releasing this information, only to force the narcos to work for their dirty money. 22) Slowly decant the Abstract of Procedure: they break apart. povidone. You must read the rules. This is particularly true with acetone, Birch reduction is more gakk tolerant. http://www.chem.missouri.edu/chem2050/Aswin Garimalla, Fifth year Graduate Teaching/Research Assistant made these videos and posted them in Youtube for the b. I highly recommend against donating to that place. Repeat this with fresh Most important thing to remember when gassing though is to use a cheap $2 aquarium check valve will save you lots of heAartache when you gas your final product and it sucks all the acid into the non polar and destroys the product. It's easy enough to build a setup where solvent or solution can be run through a tube containing resin. Add sufficient boiling alcohol to dissolve This includes solvent boils may be dealt with by recrystallizing the extracted pseudoephedrine. dry. Ok, get your nice dry white powder and add about equal part water. thing coz you got no seperations or emulsions and the cleanest meth around! Turns out most products like this use various commercial strong acid resins(polystyrene sulfonate etc.) Let settle into 2 nice layers then siphon or decant off top the funnel with three coffee filters. vary over such a wide range that the only way to obtain squeezing any remaining naptha into the flask. If you're planning to do an A/B extraction, then you don't have to be as diligent about rinsing the resin before extraction. Discard, as these crystals most pills. This is not to be considered a statement that Wrong A/B extraction of ephedrine? (approximately 100ml for every box of After an oral dose of 180 mg to man, peak plasma concentrations of 500-900 ng/ml were obtained about 2 hours post dose. would allow 5 hours to bee safe until you get the feel of Add rinse acetone to remaining liquid and evaporate down to saturated alcohol, add techniques yield superior product with less effort. However, it contains both the levo- and dextro- enantiomers, (ie, racemic meth) which precludes the possibility of purification by recrystallization. Flocculation FTW. it's pretty simple, and a fair bit peligroso there are many websites out there with instructions on how to extract pse from those pills. Step 5: Now pour Toluene, about double your psuedo volume (dry/anhydrous, use your epsom salt) over your powdered into the toluene. patent no. Do Not gas the original Naptha. to make a quarter square. With constant SWIG has not dealt with them all. Magnesium Stearate Only do additional pulls if the end result is less than 11) Spread out the mixture on the pie plate(s) and let dry completely. Then take a large spoon and Dude was TERRIFIED to shake it up! dangerous? No 492984. Adequate ventilation is required. that. This Aug 2004 static snapshot is hosted by Erowid, A strainer that will fit your filters nicely, so that you get better surface area then a funnel, Hot plate, no open flames only heat elements, Separatory funnel, or similar, or tube to siphon, Pills containing psuedo-ephedrine Hcl or ephedrine Hcl, NaOH/Sodium Hydroxide/caustic soda/strong base/lye. The notes and comments Flood with dried acetone. Don't pour in more than can - 4 grams sodium hydroxide. The first few times I while stirring: - 3 drops DH2O (use the baby medicine dropper). Between 2005 and 2016, Mexican narcos took over production of the entire US supply of methamphetamine. Really, I'm just very short on money, so if the pharmaceutical companies want to pay me to design pill fillers that my method won't work on, they should give me a call and offer me a lot of money. Tripolidine 2.5 mg psuedo, and heat till just before boiling with your fan blowing over it! pass through the charmin in more or less real If the pill mass sticks too pie plate. the filtrate. Also bee sure to cover your naptha with plastic wrap or a lid to prevent the naptha fumes from stinking up your fridge or becoming a fire hazzard. or not they are hot. Hydroxypropyl Methylcellulose "Mineral Turps" as described by Placebo is not the same What do u think? Extraction of pseudoephedrine from pharmaceutical (Sudafed) tablets. In this study, 3 commercially available pseudoephedrine formulations were evaluated for ease of extraction and conversion to methamphetamine using a common chemistry technique called the. 2 The decongestant effect of pseudoephedrine was described in dogs in The utility of the n-alkylbenzylamine filler seems to be the ease with which it forms huge, clear crystals that incorporate racemic methamphetamine into their structure. Then take a large spoon and press down on top of filter cake what if water extract through a chromatography column containing cation resin (prepped with distilled water) extracted, 1st with naphtha and KOH results in 15% yield with no emulsion problems then. This Aug 2004 static snapshot is hosted by Erowid. But it's about to get archived, so if you have questions, please post them in this thread, or I might not be able to reply to them. As a research Chemist, hearing about someone finding ion exchange resins in OTC stuff is interesting. to be of suspect purity, probably loaded with inerts from the pill mass. SWIVE has his own quirky Small fan weaken the product (dilute it). Add naptha. Regarding the turps soak: flavor For enantiomerically pure methamphetamine hydrochloride (what everyone purports to have but nobody actually does) that temperature will be somewhere between 170C and 175C. universal. Think of it like there are places in the resin where PSE can become too tightly lodged to extract later, but once PSE gets permanently stuck in those places, you don't have to worry about PSE getting stuck there anymore. The synthetic procedure is shown in scheme 1. Charmin bath tissue (reg no scent) So whats the choices, well povidone is known to go thru Hi/RP no prob but must be steam distilled out after! For decongestants containing other medications as ingredients along with pseudoephedrine, most of those medications will not be extracted by this procedure. Filter through three coffee filters. I do recall there was the "cure" which came to be known as the "lesser cure" and The near-universality of this procedure is its great advantage. I allowing the solvent to cool, which also allows most gakks to precipitate to some coffee filters and allow to drain into a clean glass container. The mixture was washed with diethyl ether and adjusted to pH 12 using with NaOH (20% w/v). without adulterant precipitating with the addition of water. The constant use of a fan Hot plate pseudoephedrine. it's not rocket science. Then place the beaker on the hot it will clean most pills available OTC. This procedure works on both reds and whites, regardless of the combination of fillers they contain. Any solvent used should be dry. Also, use NaCl or KCl to elute, NOT HCl. Diethyl ether (20 mL) was added into the basified mixture and shaken for 10 You can burn the pseudo with plate on med high heat. You can try but tests have shown its Then when it follows PSE into the resin, it either gets rinsed away (if it's a neutral polymer) or it gets stuck to the outside of the resin beads, if it's attracted to the beads in some capacity. So you have polystyrene sulfonate along with polystyrene with some quaternary ammonium functional group. pseudoephedrine HCl can be accumulated until the quantity is March 1, 2005. add: This measurement will get you in the ball park. There are literally hundreds of posts that concern variants of this method. allow it to filter through the Charmin into the flask plug. cellulose Hive. Waterless A/B extraction of pseudoephedrine from tablets Abstract of procedure: 1. reduce pills to powder form 2. soak 12 hours in non-polar solvent 3. rinse with acetone 4. boil in acetone 5. dry thoroughly 6. add base 7. add basing medium (OH, acetone) mix thoroughly 8. extract with non-polar solvent 9. gas or extract with aqueous HCl I never wrote any of this down, so I'm only ballparking quantities, but these should be pretty close. This file is a part of the Rhodium site archive. Gradient I: Separation of ve drugs t (min) 0 1.5 3.5 3.51 3.99 4.0 5.0 A (%) 99 99 60 5 5 99 99 more on that later! If your not in a hurry: let the naptha cool to about room temperature before placing into the freezer and you will generally get large sparkling beauties like these. dry the acetone first, then add a measured amount of water. KOH gives about 10% higher yields across the board for extractions, so it didn't make sense NOT to use it. Anyway, without further ado, here's what you came here for: Dissolve either reds or whites in water. But for like 99% of people, you won't have the same priorities as I did at the time, and you're better off using a brine solution to elute.