This leaflet tells you what to expect after you have had your primary or booster vaccination. 03-14-2021 08:37 PM. In the study, following the first dose of vaccine, there were: Meanwhile for people who had a coronavirus infection, there were approximately: There was also an increased risk of bleeds on the brain in the first seven days after a positive Covid test, but risks returned to a normal, baseline level within a month. Best Pract Res Clin Rheumatol. 2020;3265. If your symptoms get worse or you're worried, call 111. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Lung cancer symptoms: The simple finger test to find out if youre at risk of the disease, Type 2 diabetes: 'Foot drop' is warning sign, Vitamin B12 deficiency: Irreversible signs, Covid vaccine side effects: Why some people have a severe reaction, Covid new strain: Dr warned immunity from vaccine 'will be blunted', Covid vaccine: The six side effects you might have after jab. 2020;35(5):15459. Federal government websites often end in .gov or .mil. You can change your cookie settings at any time. The most recent research on the Omicron variant suggests it lives longer on surfaces than previous coronavirus variants. what happens after one dose of pfizer or moderna vaccine? For most people, however, the . In: Clinical Virology. Case series of acute arthritis during COVID-19 admission. These set of weekly results lag behind real-time figures, with the report covering the period from December 9 to February 21. But Cennimo said some earlier research suggests that some drugs may affect the immune response to vaccines. Clinical trials are where a vaccine or medicine is tested on volunteers to make sure it works and is safe. More often after the second dose Most people with allergies (including food or penicillin allergies) can be vaccinated against COVID-19. Cheung S, Delgado Fuentes A, Fetterman AD. 2021 Jun;21(6):803-812. doi: 10.1016/S1473-3099(20)30987-7. Tehran University of Medical Sciences, Tehran, Iran, Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Clinical Research and Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Beheshti Blvd, Qom, Iran, Tahereh Eftekhari,Rasoul Shajari&Maryam Masoumi, You can also search for this author in @AKgirl2- If the pain persists, you should probably have it checked out by a doctor. MM, TE and RS carried out the physical examinations. 2006;332(2):902. You should be able to resume activities that are normal for you as long as you feel well. Disclaimer. | Easy Read. Search NHS Inform - Click here to submit this form, Show Long-term effects of COVID-19 Navigation. Covid vaccines and rare clots - what do we know? Pain, swelling or bruising after intense or repetitive exercise. Clinical symptoms were resolved after being treated using a combination of indomethacin and depot methyl-prednisolone for 14days. Best Pract Res Clin Rheumatol. Antibodies are proteins made by the immune system to fight viruses like SARS-CoV-2. Google Scholar. Background: You can rest and take the normal dose of paracetamol (follow the advice in the packaging) to help make you feel better. California Privacy Statement, Visit our coronavirus hub and follow our live updates page for the most recent information on the COVID-19 pandemic. Pfizer Says Bivalent COVID-19 Booster Significantly Increases Antibodies to Fight Omicron. https://doi.org/10.1097/01.JAA.0000558320.47868.2f. 2014;67(1):4651. Over 45 years of age, pain worse when walking and stiffness after moving. Keywords: She has lung and kidney damage (only one kidney left) as a result of extensive . Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, COVID-19 vaccination: what to expect after vaccination, What to do if you are concerned about your symptoms. Jen Mills Wednesday 7 Apr 2021 10:47 pm. There were 10 frequently reported reactions to the jab, happening to more than one in 10 people, which included: Again, these reactions ranged from mild to moderate but passed within a few days following the injection. People (except those who are moderately or severely immunocompromised) who first received a J&J/Janssen COVID-19 vaccine and got it again for their booster may also receive a booster of an mRNA COVID-19 vaccine (Pfizer-BioNTech or Moderna).Get the mRNA booster at least 2 months after the most recent J&J/Janssen booster. Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D. The CARE guidelines: consensus-based clinical case report guideline development. Both Pfizer and Moderna have acknowledged that their vaccines could induce side effects that are similar to symptoms associated with mild Covid-19, such as muscle pain, chills and headache. A few days ago, the lower back and hip pain started up again. Careers. | Audio An official website of the United States government. 2023 Feb;19(2):67-73. doi: 10.1016/j.reumae.2022.03.005. Unable to load your collection due to an error, Unable to load your delegates due to an error. Fatigue has been reported by roughly 63 percent of research subjects. This site needs JavaScript to work properly. Since reactive arthritis typically happens due to an infection, the patient was tested for Brucellosis (Using Wright, Combs Wright, and 2ME tests) and Tuberculosis (Using PPD skin test) as two of the primary organisms causing ReA. Some earlier research in the laboratory suggests that fever-reducing pain medications may blunt the antibody response to vaccination, but its not clear what this means in the real world. government site. Kishimoto M, Lee MJ, Mor A, Abeles AM, Solomon G, Pillinger MH. However, ultrasound images of the soft tissues around the hip revealed an increase in the thickness of synovium and articular effusion in the hips neck with a 7mm diameter (Fig. 2021 Feb;21(2):181-192. doi: 10.1016/S1473-3099(20)30843-4. No redness or warmth was found around the joint, as well as no mouth ulcers, rashes, Raynauds, or alopecia. Pathogenesis of ankylosing spondylitis and reactive arthritis. 2021 Jul 30;74(7-08):273-276. doi: 10.18071/isz.74.0273. Patient should abduct shoulder by 60 degrees and place hand on the ipsilateral hip (Figure 1). This injection seemingly led to more adverse side effects than the Pfizer jab. Article If your arm is particularly sore, you may find heavy lifting difficult. The patient was started on 100mg indomethacin twice a day and 80mg IM depot prednisolone based on this diagnosis. https://doi.org/10.1186/s40794-021-00142-6, DOI: https://doi.org/10.1186/s40794-021-00142-6. The MHRA makes sure the vaccines meet strict international standards for safety, quality and effectiveness. Most of these are mild and short-term, and not everyone gets them. Omar IM, Weaver JS, Samet JD, Serhal AM, Mar WA, Taljanovic MS. Radiographics. doi: 10.7759/cureus.26702. Millions of people have had a coronavirus (COVID-19) vaccine and the safety of the vaccines continues to be monitored. The authors of this study said that this raises the possibility that NSAIDs might also affect the immune response to coronavirus vaccination. Our website services, content, and products are for informational purposes only. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. It will help to reduce the risk of you passing on the virus. An increase in thickness is seen in the synovium and also articular effusion in the hips neck with a 7mm diameter, MRI of the pelvis. The Centers for Disease Control and Prevention (CDC) issued similar guidelines for how to deal with the side effects of the two mRNA vaccines that have been approved in the United States. | 2023 Feb 1;100(2):170-173. doi: 10.1097/OPX.0000000000001988. View our Twitter - (This will open in a new window). Meanwhile, the European Medicines Agency (EMA) has said it is investigating possible side effects of COVID-19 vaccines produced by Pfizer and Moderna. However, an itchy throat is more commonly associated with allergies. Primary meningococcal arthritis in a COVID-19 18-year-old man: a case report and review of the literature. 2 from Pfizer or Moderna, many people feel an all-over malaise, with chills, potential for fever, and body aches. After ultrasound and MRI, she was diagnosed with reactive arthritis inflammation in the hips neck. "Serious adverse events that are unrelated to the vaccine are unfortunately likely to occur at a similar rate as they would in the general population.". Wiley; 2016. p. 124365. eCollection 2022 Jul. Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality. However, improper. Informed consent was obtained from the patient for publication of this case report and any accompanying images. 2004;18(5 SPEC. Efficacy and risk of mRNA vaccination in patients with autoimmune inflammatory rheumatic diseases. Bethesda, MD 20894, Web Policies It is important to note that the Covid vaccines can still engender a number of side effects, from mild to serious, although the benefits of getting vaccinated far outweigh the risks posed by the virus. READ MORE:Lung cancer symptoms: The simple finger test to find out if youre at risk of the disease. @AKgirl2 I had a horrible reaction to the second Pfizer vaccine (I posted about it in Wellness) but the worst of it only lasted 36 hours. Ono K, Kishimoto M, Shimasaki T, Uchida H, Kurai D, Deshpande GA, et al. That's why we need large studies of real-world data, like this one, which looked at the healthcare records of millions of people. Kim TH, Uhm WS, Inman RD. Reactive arthritis in patients attending an urban sexually transmitted diseases clinic. I would think your issues may be from something else. All of the authors have no conflict of interest to declare. The approved COVID-19 vaccines have been tested on thousands of people in the UK and around the world, including: All vaccines used in the UK must be approved by the independent Medicines and Healthcare products Regulatory Agency (MHRA). She is a teacher that got covid and was not as ill as when they gave her shots. J Am Acad Dermatol. RMD Open. New-onset inflammatory arthritis after COVID-19 vaccination: A systematic review. Toivanen A, Toivanen P. Reactive arthritis. The estimated "R" number the reproduction rate has remained between 0.6 to 0.9 across the UK, suggesting the size of the pandemic is shrinking. Maryam Masoumi. Doctors say the landmark UK study provides further reassurance that being vaccinated offers the best protection for overall health. 2023 Feb;26(2):267-277. doi: 10.1111/1756-185X.14482. Kristen has had ankylosing spondylitis (AS), a type of inflammatory arthritis that causes debilitating back and hip pain, as well as other symptoms, for more than 20 years. PubMedGoogle Scholar. The preclinical evaluation of Covid vaccine AZ (study 514559) evidenced vaccine distribution) to various body tissues beyond injection site including sciatic nerves [4]. There have been 19 side effects reported in those receiving the Pfizer Covid vaccine. After shot No. If you feel unwell or very tired you should rest and avoid operating machinery or driving. Coronavirus (COVID-19) vaccination. Click here to toggle the visibility of the search bar. SARS-COV-2 usually presents with respiratory symptoms but can have various other manifestations and sequelae. SARS-COV-2 usually presents with respiratory symptoms but can have various other manifestations and sequelae. 2022;18(4):346-351. doi: 10.2174/1573397118666220211155716. Clinical trials are where a vaccine or medicine is tested on volunteers to make sure it works and is safe. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. You don't have to spend long online to stumble on posts falsely claiming Covid vaccines are causing all kinds of frightening side effects. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. They did not see the same pattern of increased risks with the Pfizer jab. 2). Staff giving the vaccine are trained to deal with allergic reactions and treat them immediately. She showed dramatic improvement starting 5days after her visit and reached remission after 14days. I know of 2 people not related that had sever lower back pain when they had covid. PMC According to data published by Public Health England (PHE), leg pain has not been specifically associated with either the AstraZeneca or Pfizer vaccine. | Researchers hope to expand their study to consider second vaccine doses and booster doses. British Sign Language (BSL) The site is secure. Epub 2022 Jul 22. Reverse Transcription Polymerase Chain Reaction, Mean Corpuscular Hemoglobin Concentration, Serum Glutamic-Oxaloacetic Transaminase (Aspartate aminotransferase), Serum Glutamic-Pyruvic Transaminase (Alanine transaminase). I would recommend waiting until someone experiences side effects of fever or pain that require fever-reducing or pain-reducing medications, she said, and not to take them as a prophylaxis to prevent vaccine related symptoms.. But these records on their own cannot tell us whether they were caused by the jab. Read about our approach to external linking. PMC If your pain in your lower back and left hip s not resolving it may be a sign of a problem. J Orthop Case Rep. 2021 Mar;11(3):79-84. doi: 10.13107/jocr.2021.v11.i03.2098. Side effects of the coronavirus vaccines developed by Pfizer and Moderna are common, and they become more frequent after the second dose. Here's How to Tell. Metyas S, Chen C, Aung T, Ballester A, Cheav S. Curr Rheumatol Rev. Well send you a link to a feedback form. Anyone having these issues? This is contingent on the pandemic not putting extreme pressure on the overworked NHS. MM conceived and planned the visit. One thing they looked for was a rare condition called Guillain-Barre Syndrome (GBS) known to be associated with certain infectious diseases and linked to some other vaccines. doi: 10.1136/rmdopen-2022-002519. I never had back/hip pain. These symptoms normally last less than a week. The side effects show that the vaccine is teaching your immune system how to recognize and attack SARS-CoV-2, the coronavirus that causes COVID-19, if it encounters it. There has been 963,862 people who have now received their second dose of the vaccine, as of March 4. Back to Knee Surg Sports Traumatol Arthrosc. 23 November 2022, Feedback display message, this and the title will be overided by Javascript. Most side effects are mild and should not last longer than a week, such as: a sore arm from the injection feeling tired a headache feeling achy feeling or being sick https://doi.org/10.1097/01.bor.0000163447.44037.c4. Zhang Y, Zeng G, Pan H, Li C, Hu Y, Chu K, Han W, Chen Z, Tang R, Yin W, Chen X, Hu Y, Liu X, Jiang C, Li J, Yang M, Song Y, Wang X, Gao Q, Zhu F. Lancet Infect Dis. But additional studies would be needed to know for certain. Privacy COVID-19-associated arthritis: an emerging new entity? National Library of Medicine Learn how it feels and how to manage it. 23 years old.. got my first dose of the Pfizer vaccine on March 25th (same day as predicted ovulation) and was expecting my period on April 9th. Toivanen A, Toivanen P. Reactive arthritis. 1996;39(7):11727. Chest pain Shortness of breath Feelings of having a fast-beating, fluttering, or pounding heart Myocarditis and pericarditis have rarely been reported. Previous studies have reported ReA following HIV infection as well as with dengue and chikungunya viruses [10,11,12]. Does post-COVID reactive arthritis exist? READ MORE:Pfizer vaccine: Four 'troubling' side effects that mainly follow second dose of Covid jab, "Pfizer-BioNTech COVID-19 Vaccine is still being studied in clinical trials.". It is over a month after your second dose, so this is not a short term effect or potential problem, related or not to the shot. 2023 Feb 21:1-3. doi: 10.1007/s00167-023-07332-z. Ten days after her discharge, she represented to the clinic complaining of radiating pain in her right hip, which had caused her walking difficulties. She currently takes the biologic infliximab (Remicade), which affects immune system function. official website and that any information you provide is encrypted "I also work as a GP and we want to make sure people are taking up the vaccine and booster jabs, and by doing that we will protect the health of the nation in the best way we can.". If you have a serious allergic reaction to the 1st dose of a vaccine, you should not have the same vaccine for your 2nd dose. 2020;55(5):105954. https://doi.org/10.1016/j.ijantimicag.2020.105954. Like all medicines, vaccines can cause side effects. This may include adverts from us and 3rd parties based on our understanding. Reactive arthritis in the right hip following COVID-19 infection: a case report. Express. I have heard of someone having sudden back pain the day after the second shot of Moderna's product, but it resolved by the next day. Seek treatment right away if you develop a rash, difficulty breathing, or chest or abdominal pain. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. Reports of serious side effects are extremely rare. Dont worry we wont send you spam or share your email address with anyone. Latest evidence shows that COVID-19 can lead to autoimmune reactions, including reactive arthritis. We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. HHS Vulnerability Disclosure, Help According to Pfizer's official website, side effects that have been reported with the Pfizer-BioNTech. Online ahead of print. Systemic Reactions. Shokraee, K., Moradi, S., Eftekhari, T. et al. | QVC, Q and the Q logo are registered service marks of ER Marks, Inc. 888-345-5788. | Romn PubMed This downward trend has also been seen in the number of patients admitted to hospital, so let's hope it stays that way. Federal government websites often end in .gov or .mil. But, I have not had these issues until after I received the 2nd vaccine. Like all medicines, the COVID-19 vaccines can cause side effects, but not everyone gets them. 2004;18(5 SPEC. Recurrent Acute Pancreatitis in a Patient with COVID-19 Infection. MRI revealed a fluid rim around the pelvic area,, MeSH Schools are set to return on Monday, March 8, and lots of people will be keeping their eyes on the figures. Cennimo said the pre-COVID-19 vaccine research in children found that taking a fever-reducing drug only affected the production of antibodies if the drug was taken before the injection. There are ways to manage pain that you may have after coronavirus (COVID-19). Individuals may experience shoulder pain following a COVID-19 vaccination. All data and statistics are based on publicly available data at the time of publication. Additionally, MRI revealed a fluid rim around the pelvic area, suggesting inflammation in the right hip and sacroiliitis (Fig. Doctors say the landmark UK study provides further. COVID-19 Vaccine: Key FDA Panel Supports Updated Annual Shots. Probiotic supplements can be used as one part of an immune-boosting protocol to help reduce the likelihood of coronavirus infection. Can you go back to daily activities after having your vaccine? View our Facebook page - (This will open in a new window). "We closely monitor all such events and collect relevant information to share with global regulatory authorities.". Finally, she was diagnosed as ReA after CoronaVac vaccination and was administered a single intra-articular injection of 1 ml compound betamethasone. Calabrese LH, Naides SJ. Clinical symptoms were resolved after being treated using a combination of indomethacin and depot methyl-prednisolone for 14 days. Peiris JSM. Google Scholar. To help us improve GOV.UK, wed like to know more about your visit today. Can Nigeria's election result be overturned? The MHRA makes sure the vaccines meet strict international standards for safety, quality and effectiveness. Reactive arthritis is a form of spondyloarthritis that typically manifests with the involvement of one or a few joints asymmetrically following an infection episode, classically with genitourinary or gastrointestinal microorganisms [8, 9]. No genitourinary symptoms which could have suggested a urinary tract infection were reported. As for the daily number of people testing positive for the virus, this stands at 6,573 people for the same time period. Fatty liver disease symptoms: Nail changes could signal the condition, Covid vaccine side effects: After effects 'more common' second time, Diabetes type 2 symptoms: Foot drop is a sign of high blood sugar, Coronavirus vaccine: The most common side effects of the jab exposed. So it is important to continue to follow current national guidance. J Am Acad Dermatol. The MHRA is carrying out a detailed review of reports of an extremely rare blood clotting problem affecting a small number of people who had the Oxford/AstraZeneca vaccine. Many of these posts take figures out of context from safety monitoring databases, which record health conditions experienced by people in the weeks after being vaccinated. https://doi.org/10.1016/j.jaad.2008.02.047. official website and that any information you provide is encrypted Community content from Health Unlocked - This will open in a new window. @Mersha~ Youre probably right. -. For most people, the side effects of the vaccine are mild or moderate and last only a day or two. COVID-19; Reactive arthritis; Spondyloarthritis. DON'T MISSHigh blood pressure: 75p fruit to reduce risk [TIPS]Diabetes type 2: Four sensations in the feet [INSIGHT]The habit that increases longevity by 50% [ADVICE]. With the. 2021 Oct;(319):100-102. 2020 Nov 28;12(11):e11761. 2022 Sep;8(2):e002519. Learn about causes, treatment, and. The swelling and pain nearly disappeared after 2 d. On 1month follow-up, her condition was normal. Do. All of the authors have no funding sources to declare relevant to this report. Reactive arthritis after COVID-19 infection. QVC is not responsible for the availability, content, security, policies, or practices of the above referenced third-party linked sites nor liable for statements, claims, opinions, or representations contained therein. sharing sensitive information, make sure youre on a federal The investigators examined the NHS records of 32 million adults in England to assess any rare adverse events linked to Covid vaccines. This study was approved and supervised by the Research and Ethics Committee of Qom University of Medical Sciences and Health Services. Rare neurological conditions may occur after Covid vaccination, but the risk is far higher in people who catch Covid, new research suggests. It suggests neurological complications are rare and unlikely with the Covid vaccines. doi: 10.1016/j.berh.2004.05.008. But if these drugs reduce the side effects of the vaccine, is there a chance that theyll also depress the immune systems beneficial response to vaccination? Product information on COVID-19 vaccines and medicines is available on this page. You cannot catch COVID-19 from the vaccine but it is possible to have caught COVID-19 and not realise you have the symptoms until after your vaccination appointment. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. I received my second vaccine on February 4th, and have been experiencing pain in lower back and left hip. Further attentions should be put to determine which individual is at higher risk for developing autoimmune diseases after COVID-19 vaccination. Would you like email updates of new search results? Some stiffness, pain, and swelling for several days after the vaccination is a normal reaction. An increase in thickness is, MRI of the pelvis. 2005;19(4):96380, x. https://doi.org/10.1016/j.idc.2005.09.002. 2020;10(1136):annrheumdis--2020--217914. It can also prevent you from having the long-lasting health problems experienced by some COVID-19 patients, or " COVID-19. You get any of these symptoms starting from around 4 days to 4 weeks after being vaccinated: There have been rare cases of inflammation of the heart (myocarditis) reported after COVID-19 vaccination. Reactive arthritis following COVID-19: cause for concern. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19) J Gen Intern Med. Knee Surg Sports Traumatol Arthrosc. 2023 BBC. Tropical Diseases, Travel Medicine and Vaccines Int J Rheum Dis. This case report was prepared following the CARE Guidelines [7]. ReA after COVID-19 vaccination is rare. Dont include personal or financial information like your National Insurance number or credit card details. Latest evidence shows that COVID-19 can lead to autoimmune reactions, including reactive arthritis. Prof Julia Hippisley-Cox, from the University of Oxford, said: "The really big message from this is these are very rare neurological events that might be associated with the vaccine. The .gov means its official. The Food and Drug Administrations independent vaccine advisory committee voted unanimously in favor of having all COVID-19 vaccines in the United, You may wonder whether supplementing with vitamin D can help reduce your risk of contracting the new coronavirus that causes COVID-19. Two other reactive arthritis cases following infection with SARS-COV-2 were reported, one of a 57years old man in Japan and the other of a 73years old man in Turkey [14, 15]. Lopez-Gonzales reported 4 cases of acute arthritis during COVID-19 admission, all of which had rheumatologic background diseases [13]. Accessibility The approved COVID-19 vaccines have also been tested on millions of people in the UK and around the world, including: All vaccines used in the UK must be approved by the independent Medicines and Healthcare products Regulatory Agency (MHRA). 2020;35(5):15451549. In the COVID-19 vaccine trials, people were not given an NSAID or acetaminophen before the injection, so we do not know what if any effect premedication would have, he said. | Polski This article. COVID-19 Vaccine-Related Arthritis: A Descriptive Study of Case Reports on a Rare Complication. Bookshelf It can also prevent you from having the long-lasting health problems experienced by some COVID-19 patients, or COVID-19 long haulers.. Yes, you can take OTC pain meds after getting the Covid vaccine, says CDC plus other tips for dealing with side effects. 2005;17(4):4005. 2022 Sep-Oct;42(5):1415-1432. doi: 10.1148/rg.220036. Researchers repeated their study on a smaller population of vaccinated adults in Scotland and found the same link with GBS and the Astrazeneca vaccine. Google Scholar. Dr. David J. Cennimo, an infectious disease physician and assistant professor at Rutgers New Jersey Medical School, said these are signs of an appropriate recognition and immune reaction to the vaccine.. People aged 16 and over, and some children aged 12 to 15, can also get a booster dose. Trop Dis Travel Med Vaccines 7, 18 (2021). Fergus Walsh: What does Covid-19 do to the brain? Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. By using this website, you agree to our The scientists, from the Universities of Oxford and Edinburgh, compared the levels of neurological conditions seen within a month of having a first Covid jab, to those seen within a month of a positive coronavirus test. Further attention should be paid to symptoms occurring after an episode of infection with COVID-19 to expand our understanding of the disease and the symptoms with which it can manifest. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. What you can do after youve had the vaccine, nationalarchives.gov.uk/doc/open-government-licence/version/3, having a painful, heavy feeling and tenderness in the arm where you had your injection, a new, severe headache which is not helped by usual painkillers or is getting worse, an unusual headache which seems worse when lying down or bending over or may be accompanied by, new, unexplained pinprick bruising or bleeding, shortness of breath, chest pain, leg swelling or persistent abdominal pain, feelings of having a fast-beating, fluttering, or pounding heart.